potassiumchannel相关论文
Effect of Matrine on Human Ether à go-go Related Gene (HERG) Channels Expressed in Chinese Hamster O
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General anesthesia is an unconscious state induced by anesthetics for surgery.The molecular targets and cellular mechani......
Blockade of Na+/H+ exchanger type 3 causes intracellular acidification and hyperexcitability via inh
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Exogenous H2S enhances mice gastric smooth muscle tension through S-sulfhydration of KV4.3 mediating
Objectives:H2S has been shown to have an excitatory effect on gastric motility,but the underlying molecular mechanism is......
Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone mediated by Voltage-depend
Objectives:Hydrogen sulfide (H2S) has been proposed as a gasotransmitter similar to nitric oxide (NO) and carbon monoxid......
Effects of potassium channel on neuronal apoptosis induced by oxygen-glucose deprivation with or wit
Aim: It was generally believed that excessive potassium efflux was one of the primary causes of neuronal injury after ce......
High through-put screening,single channel analysis & crystal structure reveal the selectivity,conduc
The flow of ions across biological membranes is central to physiological processes like nerve excitation, muscle cell co......
Cox2 inhibition ameliorates seizure susceptibility in a mouse model of autosomal dominant lateral te
Autosomal dominant lateral temporal epilepsy(ADLTE)is an inherited epilepsy syndrome caused by mutations in Lgi1 gene.It......
2-Aminoethoxydiphenyl borate(2-APB)is a syntheticcompound that was originally introduced as amembrane-permeable inhibito......
Molecular basis for toxin resistance of Mesobuthus martensii voltage-gated potassium channel: insigh
It remains unclear why scorpions are immune to own venoms containing various neurotoxins specific for the mammalian or i......
M-type K+ channels, encoded by the KCNQ2-5 family of genes, play key roles in the regulation of neuronal excitability.We......
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Long-term effects of imidapril on calcium and potassium currents in rabbit left ventricular hypertro
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目的：细辛系马兜铃科多年生草本植物，是临床常用中药。关于细辛的毒性和剂量问题，素有争论，极大地限制了细辛的临床应用和疗效的发挥。......
Allosteric regulation and cooperativity are essential molecular features of cellular signaling and regulation, allowing ......
Inhibitory effect of resveratrol on the proliferation of GH3 pituitary-adenoma cells and voltage-dep
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Catilan extracted from Leiurus quinquestriatus is a specific ion channel blocker.It can specifically bind chloride chann......
药物治疗心律失常在最近几年里发生了巨大变化,由于CAST试验的结果,研究焦点已从Ⅰ类抗心律失常药转到Ⅲ类抗心律失常药.近10年来......
目的 观察甲基苯丙胺(Meth)通过电压门控钾离子通道亚型1.3、1.5(Kv1.3、Kv1.5)对大鼠胎鼠小胶质细胞的损伤作用.方法 SD胎鼠原代......
目的通过离子通道芯片及Western blot实验证实先天性巨结肠(Hirschsprung disease，HD)病变肠段的钾离子通道表达与正常的结直肠存在......
随着人口老龄化的加快,心脏疾病受到了人们的高度重视,而心脏离子通道的研究一直是该领域的研究热点之一.钾离子通道作为最复杂的......
目的观察葡萄糖对豚鼠心室肌细胞膜APD,IK1,IK,ICa-L的影响.方法采用全细胞膜片技术记录单个豚鼠心室肌细胞膜的动作电位时程和离......
Effect of nitric oxide-induced tyrosine phosphorylation of calcium-activated potassium channel α sub
Objective: To study the effect of nitric oxide-induced tyrosine phosphorylation of large-conductance calcium-activated p......
花生四烯酸是一个重要的炎症介质，它可以对广泛存在于各种细胞膜表面的外离子通道进行直接的或间接的调节。花生四烯酸与通道的直接......
